Vol. 7, Issue 9, Part A (2025)

The increasing prevalence of chronic diseases worldwide has highlighted the urgent need for safe and sustainable dietary strategies that can modulate underlying pathological mechanisms such as chronic low-grade inflammation. In this context, Amaranthus, a nutrient-dense pseudocereal and leafy vegetable, has gained scientific recognition as a functional food with significant therapeutic potential. Its bioactive compounds—including flavonoids, phenolic acids, squalene, peptides, and dietary fibers—exert regulatory effects on inflammatory signaling pathways such as cyclooxygenase (COX), lipoxygenase (LOX), nuclear factor kappa B (NF-κB), and various pro-inflammatory cytokines. The present study synthesizes and analyzes available evidence on the anti-inflammatory role of Amaranthus in chronic disease management, integrating experimental findings, clinical observations, and nutritional profiling. Using systematic literature analysis and biochemical data evaluation, the article demonstrates that regular dietary inclusion of Amaranthus reduces oxidative stress, attenuates inflammatory biomarkers including C-reactive protein (CRP) and interleukin-6 (IL-6), and supports metabolic homeostasis. The findings underscore the translational value of Amaranthus as a cost-effective and culturally adaptable dietary intervention, while also emphasizing the need for larger, long-term clinical trials to establish standardized guidelines.